Tibor Nagy, the US assistant secretary for Africa, will "call for a cessation of attacks against civilians".
Workers have staged a national strike, which began on Sunday, to pressurise the ruling military government to make way for civilian rule.
Four people were killed on the first day of the strike after security forces fired tear gas and live ammunition.
The state department said Mr Nagy would "urge parties to work towards creating an enabling environment" for talks between the two sides to resume.
He will also discuss the situation with the Ethiopian Prime Minister, Abiy Ahmed, who has been trying to mediate between the military council and the opposition in Sudan, before later travelling to Mozambique and South Africa…